Author(s)

Moraes Fabricio Tarso^1*, Galvão Anderson Dourado¹, Fortaleza Dário Batista¹, Amorin Kelly Aparecida da Encarnação¹, Sousa Claudia Cristina², Honorio-França Adenilda Cristina², França Eduardo Luzia², Costa Daniel Tizo³, Santos Wagner Batista^1*

¹Institute of Exact Sciences and Earth, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil.
²Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil.
³UniRv-University of Rio Verde, Rio Verde/Go, Brazil.

To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl₄(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru⁺³ with bipy and L-trip. The spectroscopic characterization in the middle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl₂(bipy)(L-trip)]1/2H₂O. Evaluation of the antitumor potential of precursor K[RuCl₄(bipy)] showed the toxic effects on MCF-7 cell line, but did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl₂(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.

Ruthenium Compounds, Pyridine Ligands, Antitumor Activity, Tryptophan Amino Acid, MCF-7 Cells, Ligand N-Heterocyclic

Tarso, M. , Dourado, G. , Batista, F. , Encarnação, A. , Cristina, S. , Cristina, H. , Luzia, F. , Tizo, C. and Batista, S. (2020) Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds. Advances in Biological Chemistry, 10, 86-98. doi: 10.4236/abc.2020.103007.