Journal of Tuberculosis Research

Volume 7, Issue 4 (December 2019)

ISSN Print: 2329-843X   ISSN Online: 2329-8448

Google-based Impact Factor: 1.16  Citations  

Socio-Demographic Characteristics and Risk Factors Contributing Pulmonary Tuberculosis Infection and Recent Transmission

HTML  XML Download Download as PDF (Size: 294KB)  PP. 228-237  
DOI: 10.4236/jtr.2019.74022    420 Downloads   865 Views  

ABSTRACT

Host factors, environmental factors, genetic diversity and distinct phylogeographic distribution of Mycobacterium tuberculosis (MTB) contribute to regional differences in drug resistance. Bangladesh remains among the top 20 high Multi drug resistant tuberculosis (MDR-TB) burden countries of the world. This cross sectional study was conducted to identify the socio demographic characteristics and the risk factors contributing Pulmonary tuberculosis (PTB) infection. These characteristics and risk factors were further investigated among the clustered isolates. Total 60 culture isolates consist of 40 RR and 20 rifampicin sensitive (RS) isolates were enrolled in this study. Laboratory works were done in National Tuberculosis Reference Laboratory (NTRL) and Department of Microbiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All 60 samples were confirmed as MTB by MPT 64 antigen detection. Two samples were excluded for possible cross contamination and two for failing to give PCR product for most of the locus. So, finally 56 samples were further analyzed for results. Four isolates were distributed within two clusters which were belonged to Beijing lineage. Socio demographic data and risk factors analysis of this study found significant male predominance (p = 0.04) with history of smoking (p = 0.01) and previous anti-TB treatment (p = 0.012) as the significant risk factors for RR TB.

Cite this paper

Rizvi, S. , Tarafder, S. , Kamal, S. , Anwar, S. , Johora, F. and Hossain, S. (2019) Socio-Demographic Characteristics and Risk Factors Contributing Pulmonary Tuberculosis Infection and Recent Transmission. Journal of Tuberculosis Research, 7, 228-237. doi: 10.4236/jtr.2019.74022.

Cited by

No relevant information.

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.