Author(s)

S. Vidawati¹, S. Barbosa², P. Taboada², V. Mosquera²

¹Faculty of Post Graduate, National Institute of Science and Technology, Jakarta, Indonesia.
²Grupo de Física de Coloides y Polímeros, Departamento de Física de la Materia Condensada, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

This paper reports the most prominent contributions in the field of biodegradable polymeric nanoparticles from poly (lactic-co-glycolic acid) (PLGA) used as a protein/drug delivery. We use a combination of Human Serum Albumin (HSA)-superparamagnetic iron oxide nanoparticles (SPIONs) loaded PLGA nanoparticles. To obtain protein stabilization, the optimization of each step of synthesis nanoparticle is required. One of the most common problems in encapsulating protein to PLGA nanoparticles is the presence of several challenges as a problem of instability. We explained how the effect of the various sonication processing on the synthesis HSA-SPIONs loaded PLGA nanoparticles would be one of the crucial parameters for stability.

Nanoparticles, PLGA, SPIONs, HSA, Sonication

Vidawati, S. , Barbosa, S. , Taboada, P. and Mosquera, V. (2019) Effects of Sonication Processing on the Behavior of the Synthesis Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles. Advances in Biological Chemistry, 9, 179-188. doi: 10.4236/abc.2019.96014.