Journal of Biosciences and Medicines

Volume 7, Issue 11 (November 2019)

ISSN Print: 2327-5081   ISSN Online: 2327-509X

Google-based Impact Factor: 0.86  Citations  

Monitoring the Treatment of Hepatitis C Viral Infection by Molecular Techniques

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DOI: 10.4236/jbm.2019.711008    122 Downloads   272 Views  


The prevalence of Hepatitis C viral infection in Egypt is the highest rate in the world. It is a major public health problem in Egypt. The objective of this study was to detect the clearance of HCV-RNA in Egyptian patients who were recommended for combination therapy of pyglated interferon α 2a and ribavirin (PEG-interferon/Ribavirin). Ninety-five positive HCV-IgG cases were tested for HCV-RNA at baseline and at weeks 4, 12, 24, 48 and 72 of treatment with PEG-interferon α 2a/Ribavirin. The correlations between the viral parameters during and after treatment were evaluated. Patients recommended receiving PEG-interferon 2a/ribavirin combination therapy showed high response rate determined as 71.9% achieved Sustained Virological Response (SVR) from total patients, and 71.4% from patients who received 48 weeks therapy. In general, the employment of TMA provided us the accuracy of results with confidence in our work. There was a significant relation (p < 0.001) between results of Transcription mediated amplification (TMA) and response to therapy that indicate to positive correlation. The development of sensitive accurate assays for HCV-RNA detection and quantification is necessary to improve not only the assessment of the response to antiviral therapy but also our understanding of the mechanism underlying antiviral resistance.

Cite this paper

Nabil, M. , Al-Dahr, M. , Haridi, A. , Mohamed, W. , Abdalhabib, E. and Mazahari, B. (2019) Monitoring the Treatment of Hepatitis C Viral Infection by Molecular Techniques. Journal of Biosciences and Medicines, 7, 91-100. doi: 10.4236/jbm.2019.711008.

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