International Journal of Clinical Medicine

Volume 10, Issue 10 (October 2019)

ISSN Print: 2158-284X   ISSN Online: 2158-2882

Google-based Impact Factor: 0.62  Citations  h5-index & Ranking

Exosomes in Sepsis Diagnosis and Treatment

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DOI: 10.4236/ijcm.2019.1010046    406 Downloads   691 Views  

ABSTRACT

Sepsis has been redefined as a disorder of host response to infection, systemic circulation and cell/metabolic abnormalities. Exosomes are small (30 - 150 nm) vesicles produced by all cells under physiological and pathological conditions, with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells. Exosomes are natural cargoes for proteins, carbohydrates, nucleic acids and lipids. Exosomes play a central role in cellular communication and contribute to many pathophysiological processes, including immune responses and tumor progression. Exosomes have made great progress in many subject areas, and their potential role in sepsis is now being explored. In this review, several topics are mentioned. Firstly, we discuss the biological characteristics and functions of exosomes. Next, we focus on the diagnostic and therapeutic potential of exosomes in sepsis. Finally, we discuss some of the problems encountered by the current exosomes research institute. Therefore, the exosomes with combined diagnostic and therapeutic functions play a huge clinical application for the future research in sepsis.

Cite this paper

Huang, M. , Deng, H. , Li, J. , Tao, X. and Jia, B. (2019) Exosomes in Sepsis Diagnosis and Treatment. International Journal of Clinical Medicine, 10, 565-575. doi: 10.4236/ijcm.2019.1010046.

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