Open Journal of Gastroenterology

Volume 9, Issue 8 (August 2019)

ISSN Print: 2163-9450   ISSN Online: 2163-9469

Google-based Impact Factor: 0.48  Citations  

Epidemiological and Serological Profile of Hepatitis B Virus in an Urban Area in Mali

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DOI: 10.4236/ojgas.2019.98018    379 Downloads   709 Views  

ABSTRACT

The objective of our study was to evaluate hepatitis B virus (HBV) infection in an urban population. This longitudinal study was conducted in Bamako District and Kati Commune. After a preparatory phase, the persons who accepted the protocol were assessed for HBsAg. HBsAg carriers had blood collection for HBeAg assay, viral load assessment, genotyping, DNA mutation testing, and severity of hepatic fibrosis and necrosis. At the end of this study, 1475 persons were included, of which 195 had HBsAg positive confirmed, that is to say 13.97%. The mean age of HBsAg positive patients was 35.11 ± 11.12 years with a sex ratio of 2.68. HBeAg was found in 8.9% of the patients tested for this antigen. The viral load was undetectable in 10.52% of patients and greater than 2000 IU/mL in 32.24% of cases. Fibrosis ≥ F2 and necrosis ≥ A2 were found in respectively 19.72% and 6.80% of cases. Genotype E was found in 91.6 patients and an R249S mutation observed in 39.04% of cases. Conclusion: HBV infection has a serious impact on socio-economic development in Mali because it affects mainly the young male population, hence the need to organize preventive measures effectively.

Cite this paper

Konaté, A. , Coulibaly, H. , Samaké, K. , Dicko, M. , Dakouo, R. , Kaya, A. , Tounkara, M. , Guindo, H. , Maiga, A. , Dembélé, M. , Traoré, H. , Diarra, M. and Maiga, M. (2019) Epidemiological and Serological Profile of Hepatitis B Virus in an Urban Area in Mali. Open Journal of Gastroenterology, 9, 158-163. doi: 10.4236/ojgas.2019.98018.

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