Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial - Open Journal of Obstetrics and Gynecology

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OJOG> Vol.9 No.6, June 2019

Open Journal of Obstetrics and Gynecology

Volume 9, Issue 6 (June 2019)

ISSN Print: 2160-8792 ISSN Online: 2160-8806

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Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

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DOI: 10.4236/ojog.2019.96089 401 Downloads 794 Views

Author(s)

Nwafor Johnbosco Ifunanya^*, Ibo Chukwunenye Chukwu, Obi Chuka Nobert, Onwe Blessing, Ugoji Darlington-Peter Chibuzor, Onuchukwu Victor Uchenna

Affiliation(s)

Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria.

ABSTRACT

Objective: To evaluate the efficacy of tranexamic acid for prevention of postpartum haemorrhage among women undergoing cesarean section who were at high risk of postpartum hemorrhage. Materials and Method: This was a double blind randomized controlled trial conducted at the Alex Ekwueme Federal University Teaching Hospital Abakaliki from January 2016 to December 2017. One hundred and sixty-eight parturients at high risk of postpartum haemorrhage who underwent caesarean section were randomly assigned to receive either tranexamic acid or placebo prior to skin incision. Results: The result of the study showed that the need for additional uterotonic was higher in women in the placebo arm when compared with women in the tranexamic arm of the study (7.4% versus 33.3%, respectively). The incidence of primary post-partum hemorrhage (blood loss > 1000 ml) was significantly lower in the tranexamic acid group compared to placebo group (11.9% versus 50%, respectively, P-value < 0.0001). Conclusion: Intravenous tranexamic acid given prior to skin incision at caesarean section reduced the need for additional uterotonics and incidence of primary postpartum among high risk women.

KEYWORDS

Tranexamic Acid, Maternal, Mortality, Postpartum, Haemorrhage

Cite this paper

Ifunanya, N. , Chukwu, I. , Nobert, O. , Blessing, O. , Chibuzor, U. and Uchenna, O. (2019) Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial. Open Journal of Obstetrics and Gynecology, 9, 914-922. doi: 10.4236/ojog.2019.96089.

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