Author(s)

A. K. M. Shahidur Rahman¹, Md. Arifuzzaman Sohel², Farjana Rahman Bhuiyan², Fahad Al Shatil Ashrafee¹, Md. Kabir Hossain¹, Syed Fazlul Islam¹, Mohammad Ibrahim Ali³, Rahelee Zinnat²

¹Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
²Department of Biochemistry & Cell Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh.
³Department of Urology, Dhaka Medical College Hospital, Dhaka, Bangladesh.

Background: Impaired fasting glucose (IFG) is a prediabetic condition and is a high-risk state for developing diabetes and associated complications. The aim of this study was to explore the association of vitamin D with insulin secretory function among the IFG subjects. Materials and Methods: This was a prospective cross-sectional study conducted in the Department of Biochemistry and Cell Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; from June 2016 to May 2017, on forty-six (46) IFG subjects. Serum blood glucose was measured by glucose-oxidase method, Fasting serum lipid profile (Total cholesterol, TG and HDL-c); liver enzyme like alanine aminotransferase (ALT) was measured by enzymatic-colorimetric method; Serum creatinine was measured by colorimetric kinetic method; Serum Insulin and vitamin D [25(OH)D] were measured by ELISA method; insulin secretory capacity (HOMA%B) and insulin sensitivity (HOMA%S) were calculated by Homeostasis Model Assessment (HOMA) using HOMA-CIGMA software. Results: Among 46 IFG subjects, 22 (47.8%) were male and rest 24 (52.2%) were female and their mean age was 40 (±8) years. Mean fasting serum glucose level of the study subjects was 6.33 (±0.23) mmol/l and mean postprandial serum glucose level was 7.23 (±0.41) mmol/l. Mean serum vitamin D level of the study subjects was 26.54 (±8.83) ng/ml. Mean HOMA%S, HOMA%B and HOMA%IR of the total study subjects were 48.34 (±16.70), 102.16 (±23.13) and 2.28 (±0.70) respectively. Insulin secretory capacity (HOMA%B) was significantly higher (p = 0.047) in the subjects having higher vitamin D [25(OH)D level ≥ 20 ng/ml] compared to the subjects having lower vitamin D [25(OH)D levels < 20 ng/ml]. Conclusion: High prevalence of hypovitaminosis D exists among IFG subjects. Vitamin D is associated with insulin secretory function in IFG subjects. Population based prospective studies using larger sample size should be done to confirm the results.

Impaired Fasting Glucose (IFG), Insulin Secretory Capacity, Insulin Sensitivity, Prediabetes, Vitamin D

Rahman, A. , Sohel, M. , Bhuiyan, F. , Ashrafee, F. , Hossain, M. , Islam, S. , Ali, M. and Zinnat, R. (2019) Serum Vitamin D Associated with Insulin Secretory Function in Impaired Fasting Glucose Subjects. Journal of Biosciences and Medicines, 7, 83-98. doi: 10.4236/jbm.2019.71008.