Hypofractionated versus Conventionally Fractionated Radiotherapy in Post-Mastectomy Breast Cancer Patients - Journal of Cancer Therapy

JCT > Vol.9 No.11, November 2018

Journal of Cancer Therapy

Volume 9, Issue 11 (November 2018)

ISSN Print: 2151-1934 ISSN Online: 2151-1942

Google-based Impact Factor: 0.30 Citations h5-index & Ranking

Hypofractionated versus Conventionally Fractionated Radiotherapy in Post-Mastectomy Breast Cancer Patients ()

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DOI: 10.4236/jct.2018.911078 1,605 Downloads 3,886 Views Citations

Author(s)

Fatma M. F. Akl^1*, Ashraf Khater²

Affiliation(s)

¹Clinical Oncology & Nuclear Medicine Department, Mansoura University, Egypt.
²Surgical Oncology Department, Oncology Center, Mansoura University, Egypt.

ABSTRACT

Background & Objective: Hypofractionation has been used in curative setting in breast conservative surgery, but still no adequate information about its application in the adjuvant setting after mastectomy in breast cancer patients. The aim of this trial was to assess the efficacy and toxicity of hypofractionation radiotherapy (40 Gy in 15 fractions) in post mastectomy breast cancer patients and to compare these results with those of post mastectomy patients treated retrospectively by conventional radiotherapy (50 Gy in 25 fractions) as regard overall survival (OS), disease free survival (DFS), locoregional disease free survival (LDFS), and toxicities. Patients & Methods: One hundred post mastectomy breast cancer patients were included into this study, they were divided into 2 groups, the 1st included 50 patients treated prospectively with hypofractionated radiotherapy regimen (40 Gy in 15 fractions), and the 2nd (control group) included 50 patients treated retrospectively with conventionally fractionated radiotherapy regimen (50 Gy in 25 fractions). Results: The 2 year overall survival were 96% & 94% respectively (p = 0.7), while the disease free survival were 91% & 89.8%, respectively (p = 0.9), and the LDFS were 95.8% & 93.3%, respectively (p = 0.9), G1 acute dermatitis was observed in 22 (44%) & 25 (50%) patients in group I & II respectively, G2 in 8 (16%) & 10 (20%) patients respectively, no G4 skin toxicity was detected. Radiation pneumonitis was observed in 2 patients (4%) only in group II. Conclusion: post-mastectomy hypofractionated radiation therapy achieved comparable survival and toxicity to the conventionally fractionated radiotherapy with the advantage of reducing overall treatment time, treatment burden & cost.

KEYWORDS

Breast Cancer, Adjuvant Radiotherapy, Hypofractionation, Conventional Fractionation

Share and Cite:

Akl, F. and Khater, A. (2018) Hypofractionated versus Conventionally Fractionated Radiotherapy in Post-Mastectomy Breast Cancer Patients. Journal of Cancer Therapy, 9, 941-954. doi: 10.4236/jct.2018.911078.

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[4]	Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review
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[5]	The Association Between Use of Hypofractionation and Treatment Completion Among Recipients of Radiation Therapy Post-Mastectomy
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[6]	EFFECTIVENESS OF CONVENTIONAL VS. HYPO FRACTIONATED RT SCHEDULES FOR CHEST WALL IRRADIATION IN BREAST CANCER TREATMENT AND …
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