Green and Sustainable Chemistry

Volume 8, Issue 4 (November 2018)

ISSN Print: 2160-6951   ISSN Online: 2160-696X

Google-based Impact Factor: 3.16  Citations  h5-index & Ranking

A Concept for a Novel Test for Chemical Parity

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DOI: 10.4236/gsc.2018.84021    339 Downloads   547 Views  

ABSTRACT

Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.

Cite this paper

Langhals, H. and Krotz, O. (2018) A Concept for a Novel Test for Chemical Parity. Green and Sustainable Chemistry, 8, 311-319. doi: 10.4236/gsc.2018.84021.

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