The Serum 25(OH)D Level in Patients with Atypical Femoral Fracture ()
ABSTRACT
Objective:
Excessive curvature of the femur has been considered to be one of the factors
associated with atypical femoral fracture (AFF). Although we clarified that
femoral curvature was markedly influenced by a low vitamin D level, very few
studies have been conducted on the direct relationship between AFF and a serum
low level of vitamin D. Therefore, we compared the serum vitamin D level
between AFF and osteoporosis patients. Methods: A total of 48 consecutive AFFs
in 36 Japanese patients were retrospectively reviewed using the medical
records, and 12 consecutive AFFs in 9 patients (AFF group) whose
25-hydroxyvitamin D (25(OH)D) levels were examined were included in this study.
As a non-AFF control group, 45 consecutive age-matched female patients with
osteoporosis (Osteoporosis group) were enrolled. We compared some laboratory
examination items, the bone mineral density, and curvature of the femur.
Results: When univariate logistic regression analysis was performed to compare
the 2 groups, Ca levels and lateral
and anterior curvatures in the AFF group were significantly greater than in the
Osteoporosis group (P < 0.05, P < 0.01, and P < 0.01, respectively),
and the 25(OH)D level in the AFF group was significantly lower than in the
Osteoporosis group (P < 0.01). We used discriminant analysis of these
extracted items to exclude the mutual influence of factors and identify factors
closely associated with AFF, and 25(OH)D, Ca and anterior curvature were
identified as significant items to differentiate these diseases (P < 0.05, P < 0.01, and P < 0.01,
respectively). Conclusion: AFF patients showed low vitamin D levels and
marked femoral curvatures.
Share and Cite:
Tsuchie, H. , Miyakoshi, N. , Kasukawa, Y. , Aizawa, T. , Abe, H. , Segawa, T. and Shimada, Y. (2018) The Serum 25(OH)D Level in Patients with Atypical Femoral Fracture.
Open Journal of Orthopedics,
8, 331-336. doi:
10.4236/ojo.2018.89036.
Cited by
No relevant information.