Two Methods for Calculating the Size Distribution of Ferritin’s Outer Diameter ()
ABSTRACT
Ferritin is a kind of iron-storage
protein widely found in animals and plants. The dynamic light scattering
(Dynamic Light Scattering) method is used in the laboratory to determine the ferritin
size. This paper presents two methods for calculating the outer diameter size
distribution of ferritin, both of which assume that ferritin is approximately
spherical. The ferritin data file was obtained from the PDB website and was
calculated using the coordinate data of the amino acids to which the amino
acids belong. The first method is based on the calculation of the sphere
center; the second method is based on the method of the farthest distance atom
pair. The outer diameter size distribution curves obtained by the two methods
are basically consistent with the experimental methods. The paper also compares
the calculation results and performance of the two methods. Both methods are
versatile and can be used to calculate the size distribution of the globular
proteins.
Share and Cite:
Zhao, X. and Gao, J. (2018) Two Methods for Calculating the Size Distribution of Ferritin’s Outer Diameter.
Computational Molecular Bioscience,
8, 115-121. doi:
10.4236/cmb.2018.83006.