Children’s health has always been a concern, under the background of a new wave of entrepreneurship, this paper uses China health and nutrition survey (CHNS) data, selects the age of the child height ratio (HAZ) score to measure children’s health, the OLS regression model, the treatment effect model and tendency to score matching (PSM), and other methods to investigate the influence of parents entrepreneurship for children’s health. The study found that at least one parent business, under the condition of children’s health is relatively low, the result is in step with the result of whether parents start a business. In addition, there are gender differences in children’s health; only children are in better health. The health endowment of parents also has an impact on children’s health. This article from the perspective of parents entrepreneurship researches entrepreneurship influence on children’s health, there are two main mechanisms, the first is money: it brings the income that is beneficial to children’s health; this article examines the entrepreneurship that can bring income premium; estimation results show that the venture has a significant positive effect on monthly income. The second is time: entrepreneurship to reduce the harm to children’s health care time; estimation results show that the entrepreneurial significantly reduces the time for children’s care; two mechanisms are negative; there is a relation of offsetting each other; parents start-ups do significantly reduce the children’s health level.