Author(s)

Asako Ota¹, Atsushi Tanemura^1*, Reika Aoyama¹, Yorihisa Kotobuki¹, Keita Kakuta², Kohei Tsujimoto³, Toshiro Tanaka³, Shigeaki Suzuki⁴, Ichiro Katayama¹

¹Department of Dermatology, Osaka University Graduate School of Medicine, Suita City, Japan.
²Department of Neurology, Osaka University Graduate School of Medicine, Suita City, Japan.
³Department of Clinical Immunology, Osaka University Graduate School of Medicine, Suita City, Japan.
⁴Department of Neurology, Keio University School of Medicine, Tokyo, Japan.

A 58-year-old woman complicated with autoimmune diseases of myasthenia gravis (MG), rheumatoid arthritis, and systemic lupus erythematosus noticed an irregular black macule on her bilateral major labia, which was diagnosed as malignant melanoma. The melanoma lesion involving the vagina, uterus, and ventral side of rectum was not operable and was treated with nivolumab and concurrent radiotherapy with good control of the MG. This resulted in remarkable tumor shrinkage, possibly due to synergistic effects of both treatments. To our knowledge, few reports have described the effectiveness of combination therapy with nivolumab and radiation for malignant melanoma. The present case showed an enhanced anti-tumor effect with combination therapy.

Anti PD-1 Antibody, Radiation, Malignant Melanoma, Myasthenia Gravis

Ota, A. , Tanemura, A. , Aoyama, R. , Kotobuki, Y. , Kakuta, K. , Tsujimoto, K. , Tanaka, T. , Suzuki, S. and Katayama, I. (2018) Successful Combination Therapy of Nivolumab and Radiation for Massive Mucosal Melanoma in Patient with Autoimmune-Myasthenia Gravis, Systemic Lupus Erythematosus and Rheumatoid Arthritis. Journal of Cosmetics, Dermatological Sciences and Applications, 8, 35-38. doi: 10.4236/jcdsa.2018.81006.