Advances in Microbiology

Volume 8, Issue 2 (February 2018)

ISSN Print: 2165-3402   ISSN Online: 2165-3410

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Posttranscriptional Control of Gene Expression and Role of Small RNAs in Streptococcus mutans

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DOI: 10.4236/aim.2018.82010    610 Downloads   1,324 Views  
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ABSTRACT

Streptococcus mutansis a key contributor to the formation of biofilms associated with dental caries disease. Living in the oral environment and developing of disease require tight gene regulation. In bacteria, gene expression is most commonly regulated at the level of transcription initiation. This control involved interactions of specific DNA sequences with regulatory proteins. A second mechanism of control of gene expression is mediated at the RNA level by several mechanisms and is generally called posttranscriptional regulation. These mechanisms include cis- and trans-acting small, non-coding RNAs, RNA-binding proteins, riboswitches, thermosensors, RNases, and Type I toxin-antitoxin systems, and may result in changes in RNA stability, efficiency of ribosome binding, translation initiation, and transcript secondary structures. Here I review the posttranscriptional regulation in S. mutans.

Cite this paper

Król, J. (2018) Posttranscriptional Control of Gene Expression and Role of Small RNAs in Streptococcus mutans. Advances in Microbiology, 8, 138-160. doi: 10.4236/aim.2018.82010.

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