Author(s)

Abdoulaye Leye^1*, Nafy Ndiaye¹, Yakham Mohamed Leye¹, Amadou Fall Cisse¹, Ngoné Diaba Diack¹, Michel Assane Ndour¹, Ameth Dieng¹, Daouda Thioub¹, Baidy Sy Kane², Alex Bahati¹, Alpha Omar Touré³, Cherif Mohamed Dial⁴, Pape Saloum Diop⁵

¹Internal Medicine and Endocrinology Department, Teaching Hospital of Pikine Dakar, Dakar, Senegal.
²Internal Medicine Department, Aristide Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
³General Surgery Department, Aristide Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
⁴Anatomo-Pathology Department, General Hospital of Grand Yoff Dakar, Dakar, Senegal.
⁵General Surgery Department, General Hospital of Grand Yoff Dakar, Dakar, Senegal.

Introduction: Management of pheochromocytoma faces different challenges leading to misdiagnosis and therapeutic delay in developing countries. The aim of our study was to evaluate the diagnostic and therapeutic features as well as the evolution of our management strategies in hospital setting in recent years in Dakar. Patients and Method: We carried out a retrospective study over 12 years (January 2005 to June 2017), in 4 hospitals in Dakar. We only included patients with established diagnosis of pheochromocytoma upon clinical, biological, radiological and histological arguments. Results: During this period, 16 observations have been collected and were all about female patients. The mean age at the time of diagnosis was 36.81 years. The clinical signs were dominated by hypertension found for 14 patients. At biological examination, hypersecretion catecholamine was found in 13 patients, high urinary metanephrines in 7 patients, high plasmatic metanephrines in 2 patients and raised urinary Vanyl Mandelic Acid (VMA) in 4 patients. Dosage of chromogranin A showed high level for one patient. Abdominal CT scan allowed making the adrenal origin of tumors precise. One patient presented bilateral pheochromocytoma. Before being treated surgically, all patients had had medical preparation. The surgical treatment by median laparotomy consisted of an enucleation of the tumor in 2 patients, and adrenal resection in 11patients.The evolution after surgery was favorable in 12 patients out of 13. One patient died 2 days after surgery by hemodynamic instability. In 2 patients who presented metastases, multidrug therapy with cyclophosphamide, vincristine and dacarbazine was decided after a multidisciplinary meeting, but they died before treatment. Conclusion: Management of pheochromocytomas in developing countries is obviously improving, but the mortality rate remains high. Early diagnosis and perioperative care are to be targeted for better outcome and prognosis of this rare tumor in our areas.

Pheochromocytoma, Diagnosis, Treatment, Dakar

Leye, A. , Ndiaye, N. , Leye, Y. , Cisse, A. , Diack, N. , Ndour, M. , Dieng, A. , Thioub, D. , Kane, B. , Bahati, A. , Touré, A. , Dial, C. and Diop, P. (2018) Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases. Open Journal of Endocrine and Metabolic Diseases, 8, 19-28. doi: 10.4236/ojemd.2018.81003.