Open Journal of Nephrology

Volume 7, Issue 4 (December 2017)

ISSN Print: 2164-2842   ISSN Online: 2164-2869

Google-based Impact Factor: 0.42  Citations  

Post Hepatitis C Cirrhosis in Sub-Sahara Kidney Transplant, Treated with Sofosbuvir/Ledipasvir: Report of Case and Review of Literature

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DOI: 10.4236/ojneph.2017.74011    828 Downloads   1,456 Views  

ABSTRACT

Background: Viral hepatitis C is a major public health problem in the world. The advent of direct-acting antivirals has revolutionized the taking in charge and prognosis of patients infected with the hepatitis C virus. The interest of this presentation is to draw attention to the problem of therapeutic care posed by viral hepatitis C in kidney transplant patients in C?te d’Ivoire, a country with limited resources where all direct-acting antivirals are not yet available. Patient observation: We report the case of a kidney transplant of 52 years old, chronic bearer of viral hepatitis C virus who after his kidney transplant presented, decompensated active cirrhosis. A treatment based on Sofosbuvir 400 mg/Ledipasvir 90 mg in this patient with genotype 2 for 12 weeks was initiated. A sustained virological response was observed 12 weeks after the end of treatment. Conclusion: Direct-acting antivirals offer the possibility of antiviral C treatment without interferon or ribavirin in cirrhotic renal transplant.

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Mawufemo, T. , Delphine, L. , Mélanie, T. , Albert, C. , Ibrahima, C. , Cyr, G. and Kan Clément, A. (2017) Post Hepatitis C Cirrhosis in Sub-Sahara Kidney Transplant, Treated with Sofosbuvir/Ledipasvir: Report of Case and Review of Literature. Open Journal of Nephrology, 7, 95-100. doi: 10.4236/ojneph.2017.74011.

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