International Journal of Organic Chemistry

Volume 7, Issue 4 (December 2017)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

Google-based Impact Factor: 0.58  Citations  h5-index & Ranking

Molecular Modeling and Synthesis of New Heterocyclic Compounds Containing Pyrazole as Anticancer Drugs

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DOI: 10.4236/ijoc.2017.74030    3,187 Downloads   4,627 Views  Citations

ABSTRACT

Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been tested for their cytotoxic effect on four different types of cells with malignant behavior using CA-4 as a positive control. Compounds 5b, 15 and 16 showed the foremost potent antiproliferative activities as compared to CA-4 with IC50 starting from 6.9 to 13.7 μM. Molecular docking was performed with the crystal structure of tubulin employing a potent tubulin inhibitor CA-4 as a parent molecule. Molecular study advised that 5b, 15, 16 and 17 are promising tubulin inhibitors.

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Takla, F. , Farahat, A. , El-Sayed, M. and Nasr, M. (2017) Molecular Modeling and Synthesis of New Heterocyclic Compounds Containing Pyrazole as Anticancer Drugs. International Journal of Organic Chemistry, 7, 369-388. doi: 10.4236/ijoc.2017.74030.

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