Pharmacology & Pharmacy

Volume 2, Issue 4 (October 2011)

ISSN Print: 2157-9423   ISSN Online: 2157-9431

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Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

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DOI: 10.4236/pp.2011.24036    14,238 Downloads   37,281 Views  Citations

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ABSTRACT

A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate. The structures of the compounds were confirmed by spectral data (infrared spectroscopy and 1H nuclear magnetic resonance). All of the compounds (4/5a-c and 11a-b) have been tested for their antimicrobial activities (agar disc-diffusion method) and antioxidant activities (1,1-biphenyl-2-picrylhydrazyl free radical scavenging method). The test compounds failed to show antibacterial properties (4a-c, 5b, and 11a-b) or exhibited such properties poorly (5a and 5c). None of the test compounds displayed antifungal properties. Of the compounds tested, compounds 5a-c and 11a-b exhibited promising antioxidant activities.

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T. Doan and D. Tran, "Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones," Pharmacology & Pharmacy, Vol. 2 No. 4, 2011, pp. 282-288. doi: 10.4236/pp.2011.24036.

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