In view of the problem that the breakage size is not enough to analyze the damage of the heat transfer tube of the ship nuclear power steam generator under the condition that the breakage loop cannot be isolated, this paper analyzes the damage safety analysis model based on the MELCOR program, Damage of heat transfer tubes at different break sizes (2 mm and 6 mm) to reactor power, primary loop pressure, regulator water level, core water level, vapor pressure, break flow, fuel element cladding breakage, etc. The influence of the breakage size on the damage effect of the heat transfer tube has improved the analysis and handling capacity of the damage of the heat transfer tube, and improved the reactor accident handling capacity under the condition of the damage of the heat transfer tube.