Author(s)

Layla Mhamdi, Hafedh Bohli, Younes Moussaoui, Ridha ben Salem

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We describe in this work the influence of the addition of phase transfer catalyst in heterogeneous medium liquid/liquid on the output of the reactions of Darzens and Henry. It proves that the reaction of Darzens is favoured in the presence of low base such as K₂CO₃ and Et₃N. Phase transfer catalysis is an efficient activation method in Darzens and Henry reactions. Thus, the Ethylene Diammonium Diacetate (EDD) has a comparable catalytic activity has that of quaternary ammonium salts in the reaction of Darzens.

Darzens, Henry, Phase Transfer Catalysis, Mechanism

L. Mhamdi, H. Bohli, Y. Moussaoui and R. Salem, "Phase Transfer Catalysis of Henry and Darzens Reactions," International Journal of Organic Chemistry, Vol. 1 No. 3, 2011, pp. 119-124. doi: 10.4236/ijoc.2011.13018.