Neuroscience and Medicine

Volume 2, Issue 3 (September 2011)

ISSN Print: 2158-2912   ISSN Online: 2158-2947

Google-based Impact Factor: 0.71  Citations  h5-index & Ranking

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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DOI: 10.4236/nm.2011.23031    4,326 Downloads   8,225 Views   Citations

ABSTRACT

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ß-peptide (Aß) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ß-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

Cite this paper

E. Palomer, G. ILL-Raga, M. Tajes, E. Ramos-Fernández, M. Bosch-Morató, B. Guivernau, J. Galán, J. Clarimón, C. Antúnez, M. Boada, L. Real, C. Fandos and F. Muñoz, "PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk," Neuroscience and Medicine, Vol. 2 No. 3, 2011, pp. 226-231. doi: 10.4236/nm.2011.23031.

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