Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity - American Journal of Plant Sciences

AJPS > Vol.8 No.2, January 2017

American Journal of Plant Sciences

Volume 8, Issue 2 (January 2017)

ISSN Print: 2158-2742 ISSN Online: 2158-2750

Google-based Impact Factor: 1.20 Citations h5-index & Ranking

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity ()

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DOI: 10.4236/ajps.2017.82007 1,519 Downloads 3,742 Views Citations

Author(s)

Hiroyuki Hattori¹, Kosei Yamauchi², Siaw Onwona-Agyeman³, Tohru Mitsunaga^1*

Affiliation(s)

¹Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
²Department of Medical Physiology, Texas A&M Health Science Center College of Medicine, Temple, TX, USA.
³Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.

ABSTRACT

The methanol extract of grains of paradise (GP), the seed of Aframomum melegueta, which is distributed throughout West Africa, was administered during an animal breeding test. The extract suppressed body weight gain and decreased the weight of adipose tissues in breeding mice, with a greater effect on mice fed a high-fat diet (HFD) than on those fed a normal diet (ND). Other significant effects of GP intake included increased serum triglyceride (TG) concentration and reduced hepatic total cholesterol (TC) and TG concentrations. GP intake markedly prevented fat accumulation and improved hepatic lipid metabolism in HFD-fed mice. In addition, GP extract at a dosage of 5 mg/kg body weight decreased sympathetic nerve activity (SNA) in brown adipose tissue (BAT), while capsaicin, a major component of chili pepper, activated BAT SNA. This suggested that GP exerts a potential anti-obesity effect by a different mechanism from that of capsaicin.

KEYWORDS

Anti-Obesity Effect, Grains of Paradise, Aframomum melegueta, Vanilloid, BAT SNA

Share and Cite:

Hattori, H. , Yamauchi, K. , Onwona-Agyeman, S. and Mitsunaga, T. (2017) Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity. American Journal of Plant Sciences, 8, 85-95. doi: 10.4236/ajps.2017.82007.

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