Herpes Simplex Virus 1, Cytomegalovirus and Epstein Barr Virus Detection in Patients with Chronic and Aggressive Periodontitis ()
ABSTRACT
Recent investigations suggest that the viruses of the family
Herpesviridae are associated with periodontal disease, demonstrating a possible
association with the presence of Human Cytomegalovirus (HCMV), Herpes Simplex
Virus 1 (HSV-1) and Epstein Barr Virus (EBV) in periodontal tissues. Aim: To
analyze the association between the presence of HSV-1, HCMV and EBV in patients
with chronic or aggressive periodontitis. Methods: Crevicular fluid samples
were collected from 11 patients with aggressive periodontitis (AgP), 11 with
chronic periodontitis (CP) and 11 healthy control subjects (CG). The following
clinical parameters were measured: plaque index (PI), bleeding on probing
(BOP), probing depths (PD) and clinical attachment loss (CAL). Viral detection
was performed by PCR for HSV-1, HCMV and EBV. Results: HCMV was detected in
27.3% of AgP patients but not detected in CP and healthy subjects; HSV-1 in
27.3% of AgP and CP group and in 9.1% of CG. EBV-1 was detected in 18.2% of CP
patients and 9.1% of the CG. HCMV and HSV-1 coinfection was detected in 18.8%
of AgP patients and 9.09% of viral coinfection between HSV-1 and VEB, within
the CP group. The AgP group exhibited the higher values for all clinical parameters
evaluated, respect to the CP and control group. Conclusion: The presence of
HCMV may be related to periodontal disease, specifically in cases of AgP, and
it may play a synergistic role with other infectious agents from the oral
cavity associated with the development of periodontitis.
Share and Cite:
Hernández, H. , Fernandes, A. , Escalona, L. and Correnti, M. (2016) Herpes Simplex Virus 1, Cytomegalovirus and Epstein Barr Virus Detection in Patients with Chronic and Aggressive Periodontitis.
Open Access Library Journal,
3, 1-9. doi:
10.4236/oalib.1102557.