Antiestrogenic Compounds and Breast Cancer - Open Access Library Journal

OALibJ > Vol.3 No.3, March 2016

Open Access Library Journal

Volume 3, Issue 3 (March 2016)

ISSN Print: 2333-9705 ISSN Online: 2333-9721

Google-based Impact Factor: 0.73 Citations

Antiestrogenic Compounds and Breast Cancer ()

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DOI: 10.4236/oalib.1102468 1,283 Downloads 2,656 Views Citations

Author(s)

Muhammad Asim¹, Noman Ali¹, Raheel Asghar¹, Awais Amin², Muhammad Saif Ur Rahman^3*

Affiliation(s)

¹Department of Bioinformatics & Biotechnology, Government College University Faisalabad, Faisalabad, Pakistan.
²Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
³Clinical Research Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

ABSTRACT

Breast cancer is the main threat around the world. Estrogen and estrogen receptors (ER) assume a noteworthy part in breast disease movement and advancement. Breast cancer is the most pervasive disease in women, every year more than 200,000 new cases analyzed. Estrogen receptors are expressed in 70% of all the breast cancer cases, so it is an important target for the treatment of breast cancer. Anti-estrogen compounds are of significant importance since it can be used as a therapy for breast cancer. In this review we have summarized the most important anti-estrogen compounds being used for the treatment of the breast cancer and their related molecular pathways with the hope that this will enhance our understanding to these compounds.

KEYWORDS

Breast Cancer, Anti-Estrogen Compounds, Bcl-2, GRP78, Caspase 8

Share and Cite:

Asim, M. , Ali, N. , Asghar, R. , Amin, A. and Rahman, M. (2016) Antiestrogenic Compounds and Breast Cancer. Open Access Library Journal, 3, 1-11. doi: 10.4236/oalib.1102468.

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