Journal of Biosciences and Medicines

Volume 4, Issue 6 (June 2016)

ISSN Print: 2327-5081   ISSN Online: 2327-509X

Google-based Impact Factor: 0.87  Citations  

Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera

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DOI: 10.4236/jbm.2016.46001    2,067 Downloads   2,702 Views  Citations

ABSTRACT

Antimutagenic and DNA protective effect of an extract VinOserae from Vitis vinifera grapes on oxidative DNA damage was investigated. The extract’s ability to inhibit mutagenicity induced by tert-butyl hydroperoxide (t-BHP) and hydrogen peroxide (H2O2) was determined with Ames test using Salmonella typhimurium His? TA102 strain. Inhibition values of 44.2% and 67.0% were detected for t-BHP and H2O2, respectively. A protective ability of the extract against DNA strand scission induced by hydroxyl radicals was studied with plasmid pBluescript II SK(-). The analysis of DNA strand breaks in plasmid DNA showed a significant inhibition of DNA damage.

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Rybková, Z. , Malachová, K. , Červeň, J. , Sezimová, H. and Pečinka, P. (2016) Antimutagenic and DNA Damage Protective Activities of a Grape Extract from Vitis vinifera. Journal of Biosciences and Medicines, 4, 1-8. doi: 10.4236/jbm.2016.46001.

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