Green and Sustainable Chemistry

Volume 6, Issue 2 (May 2016)

ISSN Print: 2160-6951   ISSN Online: 2160-696X

Google-based Impact Factor: 0.71  Citations  

An Eco-Friendly Synthesis of Heterocyclic Moieties Condensed with Pyrazole System under Green Conditions and Their Biological Activity

HTML  XML Download Download as PDF (Size: 610KB)  PP. 88-100  
DOI: 10.4236/gsc.2016.62008    3,000 Downloads   4,713 Views  Citations

ABSTRACT

The efficient, facile and green synthesis of 4-bromo pyrazolone by using N-bromo saccharine as valuable green reagent encouraged us to prepare some new fused heterocycles as furopyrazole, pyranopyrazole, imidazopyrazole, pyrazolothiazole, pyrazol thiazolopyrimidine, pyrazolothiazine, oxathinopyrazole, pyrazolobenzooxazine, and pyrazoloquinoxaline. The synthesis was carried out by a basic condensation of bromo pyrazolone 2 and a suitable reagent in a one-pot reaction using chitosan as a green basic catalyst. The reactions were carried out by microwave irradiation technique as a green source of energy as well as the conventional heating. The antioxidant activity of the prepared compounds was studied using 1,1-phenyl-2-picrylhydrazyl (DPPH) assay and their antibacterial activity against Gram-positive, Gram-negative bacteria and antifungal activity was evaluated.

Share and Cite:

El-Borai, M. , Rizk, H. , Sadek, M. and El-Keiy, M. (2016) An Eco-Friendly Synthesis of Heterocyclic Moieties Condensed with Pyrazole System under Green Conditions and Their Biological Activity. Green and Sustainable Chemistry, 6, 88-100. doi: 10.4236/gsc.2016.62008.

Cited by

[1] Ultrasonic‐assisted condensation of aromatic and aliphatic aldehydes with 3‐(thiophen‐2‐yl)‐5‐pyrazolone: Synthesis, characterization and stereoselective …
Journal of Heterocyclic …, 2022
[2] Ultrasound-assisted synthesis and biological activity of nanosized supramolecular coordination polymers of silver (I) with chloride, thiocyanate, and 4, 4′-bipyridine …
Journal of Molecular Structure, 2022
[3] Synthesis, Characterization and Theoretical Insights into Molecular Properties of 2-(4-fluorophenyl)-4H-chromen-4-one
Journal of Advanced Chemical Sciences, 2021
[4] Cytotoxic Activity against A549 Human Lung Cancer Cells and ADMET Analysis of New Pyrazole Derivatives
2021
[5] Ultrasound Assisted Synthesis, Molecular Structure, UV-Visible Assignments, MEP and Mulliken Charges Study of (E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl …
2021
[6] Conventional and microwave-assisted synthesis, antitubercular activity, and molecular docking studies of pyrazole and oxadiazole hybrids
ACS …, 2021
[7] Multicomponent synthesis, in vitro cytotoxic evaluation and molecular modelling studies of polyfunctionalized pyrazolo[3,4-b]pyridine derivatives against three …
Synthetic …, 2021
[8] The one-pot synthesis of some bioactive pyranopyrazoles and evaluation of their protective behavior against extracellular H2O2 and SNP in T. Thermophila.
2021
[9] Heteroannulation Routes to Bioactive Pyrazolooxazines
2020
[10] Synthesis and Crystal Structures of 4, 5-Dihydroimidazo [1, 5-b] pyrazol-6-ones
2020
[11] Synthesis and Anticancer Activity of Some Fused Heterocyclic Compounds Containing Pyrazole Ring
2020
[12] Recent developments in the synthesis and applications of furopyrazoles
2020
[13] Material Science Research India
2020
[14] “On-water” one-pot four-component synthesis of novel 1H-furo[2,3-c]pyrazole-4-amine derivatives
2019
[15] Synthesis, anticancer assessment on human breast, liver and colon carcinoma cell lines and molecular modeling study using novel pyrazolo[4,3-c]pyridine …
Bioorganic Chemistry, 2018
[16] SYNTHESIS, IDENTIFICATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME NEW N-SUBSTITUTED-2-(METHYLTHIO) BENZIMIDAZOLE CONTAINING HETEROCYCLIC RING
Global Journal of Bio-Science and Biotechnology, 2017
[17] Functional role of myrtle on the regeneration of endothelial dysfunction and the activity of lipoxygenases in ovariectomized diabetic rats
Der Pharma Chemica, 2016

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.