Author(s)

Yuan Niu¹, Chao Yan^2*

¹Medical College, Qingdao University, Qingdao, China.
²Department of Radiotherapy Oncology, Qilu Hospital of Shandong University (Qingdao), Qingdao, China.

This study aimed to investigate the effect of fullerenol combined with cisplatin on the proliferation of cervical cancer HeLa cells in order to provide new ideas and laboratory theoretical basis for the clinical treatment of cervical cancer. Cervical cancer cell line HeLa cells in vitro were treated with different concentrations of fullerenol, different concentrations of cisplatin, and different concentrations of fullerenol combined with cisplatin, after 24 h, 48 h, 72 h, microscope changes in cell morphology; MTT assay was used to determine the effect of drugs on the proliferation of HeLa cells. Fullerenol and cisplatin alone can inhibit the proliferation of HeLa cells in a dose-dependent and time-dependent manner; compared with cisplatin alone, different concentrations of fullerenol combined with cisplatin significantly increased the apoptosis rate of HeLa cells (P < 0.05). The inhibition of fullerenol combined with cisplatin on HeLa cells in vitro is more significant, resulting in a stronger anti-cancer effect.

Fullerenol, Cisplatin, HeLa Cells, Proliferation, Apoptosis

Niu, Y. and Yan, C. (2016) The Effect of Fullerenol Combined with Cisplatin on the Proliferation of Cervical Cancer HeLa Cells. Journal of Cancer Therapy, 7, 232-238. doi: 10.4236/jct.2016.73024.