Author(s)

Ahmad Sabry Abu-Khadra^1*, Rabie Saad Farag², Alaa El-Dine Mokhtar Abdel-Hady³

¹Department of Basic Science, Faculty of Engineering Science, Sinai University, Arish, Egypt.
²Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt.
³Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Arish, Egypt.

New series of Ag, Cd(II), Ce(III), Co(II), Cr(III), Fe(III), Ni(II) and Pb(II) complexes with (E)-N-(4-(2- hydroxybenzylideneamino) phenylsulfonyl) {S.S} have been synthesized. These compounds have been characterized by different physico-chemical techniques like, melting point, elemental analysis, FT-IR, UV spectroscopy, ¹H NMR spectroscopy, conductance measurements, magnetic susceptibility and mass spectral analysis. The metal ions concentrations have been determined using inductively coupled plasma mass spectrometry (ICP-MS). Spectroscopic studies suggest coordination most of complexes in a regular octahedral arrangement in 2L:1M molar ratio by two N azomethine and two OH phenolic from Schiff base {S.S} in the form of [ML₂(H₂O)₂], M metal, L ligand {S.S}. Complexes have been screened for their antibacterial {Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa)}, {Gram positive bacteria (Bacillus subtilis and Sterptococcus pneumoniae)} and antifungal (Aspergillus fumigates and Candida albicans) showing promising antimicrobial biological activity.

Biological Activity, Inductively Coupled Plasma, Synthesis, Sulfacetamide, Transition Metal Complexes

Abu-Khadra, A. , Farag, R. and Abdel-Hady, A. (2016) Synthesis, Characterization and Antimicrobial Activity of Schiff Base (E)-N-(4-(2-Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes. American Journal of Analytical Chemistry, 7, 233-245. doi: 10.4236/ajac.2016.73020.