Author(s)

Eszter Hantosi^1,2*, Zsolt Ifi¹, Sára Jeges³, József Bódis^1,2,3, Péter Tamás^1,2

¹Department of Obstetrics and Gynecology, University of Pécs, Clinical Center, Pécs, Hungary.
²The MTA-PTE Human Reproduction Scientific Research Group, Hungarian Academy of Sciences (MTA), Budapest, Hungary.
³Institute of Nursing and Patient Care, Faculty of Medicine, University of Pécs, Pécs, Hungary.

Objective: Homogenous pathogenesis of preeclampsia has been challenged. We examined the clinical characteristics of preeclamptic patients with discordant fetal growth which is one of the controversial issues in preeclampsia. Methods: Clinical index values including central hemodynamics of third-trimester preeclamptic patients with distinct fetal birth weights (group A: birth weight ≥ 50th percentile; n = 23 and group B: birth weight < 50th percentile; n = 14) were compared. Results: Pregnant women of group A were characteristically obese and edematous, but no fetal complications were observed. Patients of group B were younger, onset of preeclampsia was earlier, proteinuria was more severe, and fetal compromise was frequent. A marked difference between the two groups was noticed in central hemodynamics as the mean of CO (cardiac output) was 8.5 and 5.6 l/min in group A and B, respectively (p < 0.001). CO of less than 7.45 l/min was found to be associated with fetal birth weight below 50th percentile (OR = 15.6; 95% CI: 3.2 and 45.8, p = 0.001). Conclusions: Augmented CO in pregnancy may ensure efficient placental blood supply, but it may cause hypertension with subsequent moderate proteinuria. This condition, however, seems to be different from the “classical” preeclampsia.

Preeclampsia, Distinct Birth Weights, Distinct Hemodynamics

Hantosi, E. , Ifi, Z. , Jeges, S. , Bódis, J. and Tamás, P. (2014) Gestational Hypervolemic Hypertension Is Clinically Different from “Classical” Preeclampsia. Open Access Library Journal, 1, 1-4. doi: 10.4236/oalib.1100751.