Open Access Library Journal

Volume 1, Issue 3 (June 2014)

ISSN Print: 2333-9705   ISSN Online: 2333-9721

Google-based Impact Factor: 0.47  Citations  

Identifying the Roles of Interleukin-13 in Childhood Asthma

Download Download as PDF (Size: 259KB)  PP. 1-5  
DOI: 10.4236/oalib.1100468    863 Downloads   1,176 Views  
Author(s)

ABSTRACT

Asthma is a chronic inflammatory disease of the airways manifested by reversible airflow obstruction and airway hyperresponsiveness. While recent research has mapped several genes as possible factors predisposing to asthma, interleukin-13 remains one of the most commonly found genes in various populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause an increase in goblet cell differentiation, activation of fibroblasts, elevation of bronchial hyperresponsiveness and switching of B cell antibody from IgM to IgE. The aim of this review is to study and identify the three main single-nucleotide polymorphisms of IL-13 (IL13 R130Q, IL-13Rα1 and IL-13 A2044G) that have been linked to asthma in children, and to understand their respective roles in the pathogenesis of this disease.

Share and Cite:

Ramphul, K. (2014) Identifying the Roles of Interleukin-13 in Childhood Asthma. Open Access Library Journal, 1, 1-5. doi: 10.4236/oalib.1100468.

Cited by

No relevant information.

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.