Case Reports: Treatment-Resistant Schizophrenia with Severe Type 2 Diabetes Mellitus Treated with Clozapine ()
ABSTRACT
Objective: Clozapine is
regarded as the most effective drug for treatment of schizophrenia but has
complex adverse effects associated with hyperglycemia and diabetes mellitus.
Method: We report that clozapine was very effective to treat positive,
negative, and cognitive symptoms and well tolerated to a treatment-resistant
schizophrenia patient with severe type 2 diabetes mellitus (DM) under cautious blood-sugar
monitoring. Results: Clozapine itself and discontinuation of other psychotropic
and anticholinergic agents after switching may improve cognitive function and
adherence to the treatment regimens for schizophrenia and DM. Conclusion:
Clozapine can be administered to treatment-resistant schizophrenia patients
even with severe DM with caution.
Share and Cite:
Gon, J. , Sakamoto, S. and Takaki, M. (2016) Case Reports: Treatment-Resistant Schizophrenia with Severe Type 2 Diabetes Mellitus Treated with Clozapine.
Open Journal of Psychiatry,
6, 61-64. doi:
10.4236/ojpsych.2016.61006.