American Journal of Molecular Biology

Volume 6, Issue 1 (January 2016)

ISSN Print: 2161-6620   ISSN Online: 2161-6663

Google-based Impact Factor: 1.37  Citations  h5-index & Ranking

Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release

HTML  XML Download Download as PDF (Size: 570KB)  PP. 1-11  
DOI: 10.4236/ajmb.2016.61001    4,186 Downloads   4,966 Views   Citations

ABSTRACT

Small non-protein coding micro-RNAs are regularly exported out of cells, both in health and disease. More than ninety percent of extracellular miRNAs are associated with lower-molecular-mass complexes bound to Argonaute 2 (Ago2), nucleophosmin-1 (NPM1) and high density lipoproteins (HDL), whereas the rest (~10%) are membrane-vesicle-encapsulated within exosomes, shedding microvesicles and apoptotic bodies. Regardless of the debate of the nature of circulating miRNA as byproducts of routine cell activities or mediators of cell-cell communication, proper understanding of the molecular behaviors of miRNA in health and disease, is expected to open a new gate for the discovery of new diagnostic tools and possibly therapeutic implementation in the near future.

Cite this paper

Nassar, W. , El-Ansary, M. , Fayyad, T. and Aziz, M. (2016) Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release. American Journal of Molecular Biology, 6, 1-11. doi: 10.4236/ajmb.2016.61001.

Cited by

[1] Capitalisation des études et autres travaux sur les chaînes de valeur du maïs au Bénin
Document Technique et d’Informations (DT&I), 2019
[2] Extracellular genomic biomarkers of osteoarthritis
International Journal of Construction Education and Research, 2018
[3] The biological and diagnostic role of mirna’s in hepatocellular carcinoma
Frontiers in Bioscience, 2018
[4] The effect of water quality on the distribution of macro-benthic fauna in Western Lagoon and Timsah Lake, Egypt. I
The Egyptian Journal of Aquatic Research, 2016

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.