Author(s)

Christian Ogoegbunem Isichei^1,2, Mercy Wakili Isichei^2,3, Jean Emile Njab⁴, Johnson Ibidun Rotimi², Tinuade Abimbola Oyebode^5,6, Charles Ujunwa Anyaka^2,5, Kenneth Emeka Enwerem², Ayuba Ishiaku Affi¹, Lucius Chidiebere Imoh¹, Alexander Ogielu Abu¹, Solomon Abiola Asorose¹, Noel Omuya Amadu¹, Propser Ihenacho Okonkwo⁶, Ngozi Ijeoma Okoro⁴

¹Department of Chemical Pathology, Faculty of Medical Sciences, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
²Faith Alive Foundation, Jos, Nigeria.
³Department of Surgery, Faculty of Medical Sciences, University of Jos, Jos University Teaching Hospital, Jos, Nigeria.
⁴Department of Chemical Pathology, Bingham University, Jos Campus, Jos, Nigeria.
⁵Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Jos, Jos, Nigeria.
⁶AIDS Prevention Initiative in Nigeria (APIN), Abuja, Nigeria.

Background: We characterized baseline laboratory data of patients to identify priority treatment areas, most affected populations, anticipated clinical complications and assessed the potential burden of retention in care in Jos, Plateau State—North Central Nigeria. Methods: This study was a cross-sectional design from January 2004 to December 2005 at Faith Alive Foundation (FAF). All participants were HIV-positive and underwent pre-antiretroviral therapy counseling based on the national antiretroviral therapy (ART) guidelines and baseline laboratory testing. Data were captured on Microsoft Excel, validated on Epi Info and analyzed on SPSS version 21 at P < .05 level of significance. Results: Total of 1499 (463 men and 1036 women) participants were evaluated in this study. The age and sex related distribution of participants showed that majority (80.3% for males and 92.5% for females) were 16 - 45 years old. Amylase and creatinine were significantly higher in males than females (P = .02). Anaemia was the most common baseline abnormality (63% for females and 58% for males), while baseline CD4 count was significantly lower in males than females (P < .02) and at one-third had elevated liver enzymes (AST and ALT). Conclusion: The baseline laboratory profile of most HIV positive patients in Jos and environs of North Central–Nigeria was characterized by anaemia, elevated creatinine, and abnormal liver transaminase levels (AST and ALT). This pre-ART laboratory result suggests that HIV-positive individuals have multiple clinical abnormalities which may require more extensive care than just treating the HIV disease.

Baseline Laboratory Profile, HIV-Positive Patients, PEPFAR, HTC, Nigeria

Isichei, C. , Isichei, M. , Njab, J. , Rotimi, J. , Oyebode, T. , Anyaka, C. , Enwerem, K. , Affi, A. , Imoh, L. , Abu, A. , Asorose, S. , Amadu, N. , Okonkwo, P. and Okoro, N. (2015) Baseline Laboratory Profile of HIV Positive Patients on Antiretroviral Therapy in Jos North Central Nigeria: Implications for Pre-vention, Treatment, Care and Support. World Journal of AIDS, 5, 328-334. doi: 10.4236/wja.2015.54036.