Exploring Gender-Associated Socioeconomic Differences in Parkinson’s Disease ()
Author(s)
Robert McInnis1,
William Cavanaugh1,
Janice Weinberg2,
Marie-Hélène Saint-Hilaire1,3,
Samuel Ellias1,3,
Samuel Frank1,3,
Anna DePold Hohler1,3
Affiliation(s)
1Boston University School of Medicine, Boston, MA, USA.
2Department of Biostatistics, Boston University School of Public Health, Boston University Medical Campus, Boston, MA, USA.
3Boston Medical Center, Boston, MA, USA.
ABSTRACT
Background: Research on gender in Parkinson’s disease (PD) frequently focuses on clinical differences
between men and women. Socioeconomic factors such as race, ethnicity, insurance type,
and level of educational attainment, have not been extensively examined in relation to gender differences
in PD. The goal of this study was to identify differences in PD presentation in men and
women, and identify socioeconomic factors that may confound such differences. Methods: A
movement disorder patient database containing 445 patients with idiopathic PD was analyzed for
gender differences in motor symptoms and disease complications using linear or logistic regression.
Socioeconomic variables were then evaluated as possible confounders. Results: A greater
proportion of women were non-white (p < 0.05). Univariate analysis of gender, and multivariate
analysis controlling for age at diagnosis and socioeconomic factors were concordant in demonstrating
increased frequency of motor fluctuations and dyskinesia in women (p < 0.05). Controlled,
multivariate analysis, when compared to univariate analysis, uniquely demonstrated that women
were less likely to experience dementia and autonomic dysfunction, relative to men (p < 0.05).
Conclusion: Women with PD are susceptible to motor fluctuations and dyskinesia, but may be relatively
protected against dementia and autonomic dysfunction. Women and men with PD in our
population had different socioeconomic profiles, which may have confounded some gender-associated
differences.
Share and Cite:
McInnis, R. , Cavanaugh, W. , Weinberg, J. , Saint-Hilaire, M. , Ellias, S. , Frank, S. and Hohler, A. (2015) Exploring Gender-Associated Socioeconomic Differences in Parkinson’s Disease.
Advances in Parkinson's Disease,
4, 84-89. doi:
10.4236/apd.2015.44010.
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