Author(s)

Beáta Veliká¹, Vladimíra Tomečková¹, Krisztina Fodor², Ivan Kron¹, Pál Perjési^2*

¹Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine UPJS, Trieda SNP 1, Kosice, Slovakia.
²Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary.

UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute timepoints of the interaction. The absorbance of all studied compounds in the presence of proteins decreased after one hour of the reaction. Molecule 4a showed the strongest and fastest kinet initial interaction with both albumins.

Chalcones, Cyclic Chalcone Analogues, UV Spectra, Kinetic Measurements, Binding Constant Bovine Serum Albumin, Human Serum Albumin

Veliká, B. , Tomečková, V. , Fodor, K. , Kron, I. and Perjési, P. (2015) (E)-2-Benzylidenecycloalkanones XII.* Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry. Spectral Analysis Review, 3, 1-8. doi: 10.4236/sar.2015.31001.