Effects of Copaiba Oil on Cyclophosphamide-Induced Teratogenesis in Mice - American Journal of Plant Sciences

AJPS > Vol.5 No.23, November 2014

American Journal of Plant Sciences

Volume 5, Issue 23 (November 2014)

ISSN Print: 2158-2742 ISSN Online: 2158-2750

Google-based Impact Factor: 1.20 Citations h5-index & Ranking

Effects of Copaiba Oil on Cyclophosphamide-Induced Teratogenesis in Mice ()

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Download as PDF (Size: 2585KB) PP. 3464-3473

DOI: 10.4236/ajps.2014.523362 4,137 Downloads 5,201 Views Citations

Author(s)

Ana Carolina dos Santos Lourenço¹, José Eduardo Baroneza², Solange de Paula Ramos³, Liliane Kelen Miguel⁴, Luiz Carlos Juliani³, Aline Pic-Taylor⁵, Maria José Sparça Salles⁴

Affiliation(s)

¹Departmento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, Brazil.
²Universidade Positivo, Curitiba, Brazil.
³Departmento de Histologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
⁴Departmento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Brazil.
⁵Departmento de Genética e Morfologia, Universidade de Brasília, Brasília, Brazil.

ABSTRACT

Cyclophosphamide is an anti-neoplastic chemotherapy drug which, when administered to animals during the gestational period, provokes visceral, skeletal and external malformations. Copaiba oil obtained from Copaifera L. genus is traditionally used in popular medicine for its anti-inflammatory and antimicrobial activities. However, the effect of copaiba oil onteratogenesis remains unknown. This study aimed to investigate the possible protector effects of copaiba oil on the model of teratogenesis induced by cyclophosphamide in mice. Pregnant female Swiss mice were divided into 8 groups (n = 15). Three groups received copaiba oil, via gavage, in the following doses: 0.3 mL·Kg^-1, 0.6 mL·Kg^-1 and 0.9 mL·Kg^-1 (b.w.), associated to phosphate-buffered saline (PBS), intraperitoneal (i.p.). The negative control group received medium chain triglyceride (MCT) and PBS. The positive control group received cyclophosphamide (30 mg·Kg^-1 (b.w.)) and MCT. The three treatment groups called associated groups (A) received one of the doses of copaiba oil, via gavage and an associated dose of cyclophosphamide intraperitoneally. Copaiba oil presented a protective effect against teratogenesis induced by cyclophosphamide in the following skeletal structures: metacarpals, forepaws proximal phalanges, and tail vertebras. It also reduced the hydrocephalus frequency. These data suggest that copaiba oil could be a potential candidate for an anti-teratogenic agent.

KEYWORDS

Copaiba Oil, Cyclophosphamide, Teratogenicity, Phytotherapy, Malformations

Share and Cite:

Lourenço, A. , Baroneza, J. , Ramos, S. , Miguel, L. , Juliani, L. , Pic-Taylor, A. and Salles, M. (2014) Effects of Copaiba Oil on Cyclophosphamide-Induced Teratogenesis in Mice. American Journal of Plant Sciences, 5, 3464-3473. doi: 10.4236/ajps.2014.523362.

Cited by

[1]	Effect of cyclophosphamide administration during late gestation period on post natal survival and growth of rats
	INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2018

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