Biphasic Insulin Aspart 30 Therapy in Insulin-Naïve and Insulin-Experienced Patients with Type 2 Diabetes: Results from the Jordanian Subgroup of the A1chieve Study ()
Affiliation(s)
1Prince Hamzah Hospital, Amman, Jordan.
2King Hussein Medical Center, Amman, Jordan.
3Italian Hospital, Amman, Jordan.
4Islamic Hospital, Amman, Jordan.
5Novo Nordisk Business Area Near East, Istanbul, Turkey.
6Jabal Al Zayton Hospital, Zarqa, Jordan.
ABSTRACT
Objective: To analyse the
safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in a
Jordanian subgroup of the 24-week, non-interventional A1chieve study. Methods:
A total of 509 Jordanian patients with type 2 diabetes (392 insulin-naive and
117 insulin-experienced) starting BIAsp30, alone or in combination with oral
glucose-lowering drugs, were included. Safety and effectiveness outcomes were
analysed over 24 weeks. Results: Patients had a mean age of 55.8 years, body
mass index of 28.8 kg/m2 and
diabetes duration of 9.4 years at baseline. Two serious adverse drug reactions
of hypoglycaemia were reported. The proportion of patients who reported major
hypoglycaemic events decreased (2.4% at baseline vs. 0.2% at Week 24, p =
0.0039). The proportion of patients reporting overall hypoglycaemia increased
marginally (6.3% at baseline vs. 9.9% at Week 24, p = 0.0378), primarily
attributed to a rise in minor and nocturnal hypoglycaemia reported in
insulin-naive patients. From baseline to Week 24, the mean ± SD glycated
haemoglobin A1c level decreased from 9.8% ± 1.4% to 7.4% ± 0.9% (p < 0.001).
Significant reductions after 24 weeks were also noted in the mean fasting
plasma glucose, postprandial plasma glucose, lipids, systolic blood pressure
and quality of life (all p < 0.001), while the mean body weight increased by
1.8 ± 6.5 kg (p < 0.001). Conclusion: Overall, BIAsp 30 therapy was well-tolerated
and resulted in improved glycaemic control in this Jordanian subgroup over 24
weeks.
Share and Cite:
Haddad, J. , Haddad, F. , Nasser, R. , Al-Shudifat, A. , Annabi, F. , Sandalci, L. and Al-Kilani, M. (2014) Biphasic Insulin Aspart 30 Therapy in Insulin-Naïve and Insulin-Experienced Patients with Type 2 Diabetes: Results from the Jordanian Subgroup of the A
1chieve Study.
Journal of Diabetes Mellitus,
4, 379-387. doi:
10.4236/jdm.2014.44051.
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