Advances in Bioscience and Biotechnology

Volume 2, Issue 3 (June 2011)

ISSN Print: 2156-8456   ISSN Online: 2156-8502

Google-based Impact Factor: 1.11  Citations  h5-index & Ranking

Phylogeny derived from homodimeric endonuclease correlates with its pre-RNA substrates

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DOI: 10.4236/abb.2011.23018    4,811 Downloads   9,757 Views  

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ABSTRACT

Amongst endonuclease, the homodimeric variety is found in many prokaryotes for processing of the introns out from pre-RNAs. But as the variety and the complexity of introns rise with evolution, do the homodimeric endonuclease adapt to the changes? The correlations between evolving pre-RNAs and adapting homodimeric endonuclease in lower prokaryotes is investigated in this paper. First, we construct and observe the appearance of a long branch in the phylogeny based on homodimeric endonuclease. To appreciate the finer aspects of accelerating evolution near this long branch, we delve deeper into the pre-RNA substrates of the endonuclease. Computational evidence of an as-yet-unreported noncoding RNA gene then emerges from this study. The capabilities of homodimeric endonuclease and the complexities of its pre-RNA substrates appear to evolve in steps together.

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Mitra, S. , Das, S. , Sahoo, S. , Sinha, C. and Chakrabarti, J. (2011) Phylogeny derived from homodimeric endonuclease correlates with its pre-RNA substrates. Advances in Bioscience and Biotechnology, 2, 117-122. doi: 10.4236/abb.2011.23018.

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