Author(s)

Su-Jung Mah, Yoonjung Lee, Youn-Sic Chun, Won Hee Lim

Department of Orthodontics, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Department of Orthodontics, School of Dentistry & Dental Research Institute, Seoul National University, Seoul, South Korea.
Division of Orthodontics, Ewha Womans’ University Mokdong Hospital, Seoul, South Korea.

Purpose: The purpose of this study was to investigate the expression of MMP-9 and MMP-13 on compression side of tooth movement. Material and Methods: Twenty male Wistar rats were used for this experiment. Maxillary right first molar was moved orthodontically with a constant force of 20 g and on the side of the maxillary left first molar was used as control group. On the 4th, 10th and 17th days after experiment, 5 rats were euthanized, respectively. Histologic process was processed for immunohistochemical staining of MMP-9 and -13. Results: MMP-9 and -13 expressions were upregulated at day 4 after tooth movement. The expression of MMP-9 was not observed at days 7, 10 and 14, while the expression of MMP-13 was greatly increased at days 7 and 10. Conclusion: This study suggests that different characteristics of MMPs expression may contribute to the remodeling process of collagen fibers in the PDL during tooth movement.

Component, Tooth Movement, Pressure Side, MMP-9, MMP-13

Mah, S. , Lee, Y. , Chun, Y. and Lim, W. (2014) Expression of MMP-9 and -13 on the Pressure Side under Orthodontic Loading. Open Journal of Stomatology, 4, 412-417. doi: 10.4236/ojst.2014.48055.