It is known that acute or chronic heart failure can develop in patients with grave sleep apnea syndrome (SAS), and known to have the social problem including an accident and the decrease of the labor will. Several medical treatments are now available for SAS. We considered problems of the treatment based on the practice situation of our department about the present conditions and subsequent treatment. The subjects consisted of 306 patients. We measured Epworth Sleepiness Scale (ESS) and apnea hypopnea index (AHI) after polysomnography in all patients at the first time and 6 months later. So, it was found that AHI and ESS decreased when we could be treated in the SAS patients appropriately. It was confirmed that the choice of the appropriate regimen was important.