World Journal of Neuroscience

Volume 4, Issue 3 (June 2014)

ISSN Print: 2162-2000   ISSN Online: 2162-2019

Google-based Impact Factor: 0.23  Citations  h5-index & Ranking

The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects

HTML  Download Download as PDF (Size: 1156KB)  PP. 203-215  
DOI: 10.4236/wjns.2014.43024    4,481 Downloads   5,889 Views  Citations

ABSTRACT

Quantitative trait loci (QTLs) mapping has been performed during the past decades in an attempt to identify genes, gene products and mechanisms underlying numerous quantitative traits. It’s a strategy based on natural variations in genes and gene products, which facilitates translation from animal models to human clinical conditions. Our team has shown that the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) differ with respect to several emotionality- related behaviors, one of which (inner locomotion in the open field) was strongly influenced by a QTL (Anxrr16) on rat chromosome 4. Since then, several other studies not only corroborated the initial description of Anxrr16, but also extrapolated its effects to a broader context (rats from both sexes and regardless of the estrous cycle phase) and suggested that this same region influences other emotionality-related behaviors as well as alcohol intake. Other QTLs affecting neurobiological traits were also found on rat chromosome 4 and several candidate genes have been pointed out as possibly influencing those phenotypes. Altogether, these studies suggest that rat chromosome 4 constitutes an interesting target for the study of the molecular bases of anxiety and other traits related to emotional reactivity.

Share and Cite:

Medeiros, G. , Corrêa, F. , Corvino, M. , Izídio, G. and Ramos, A. (2014) The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects. World Journal of Neuroscience, 4, 203-215. doi: 10.4236/wjns.2014.43024.

Cited by

[1] The influence of chromosome 4 on high ethanol consumption and blood pressure
Alcohol, 2022
[2] O potencial da associação de cafeína e exercício físico sobre prejuízos cognitivos observados em modelos animais do Transtorno do Déficit de Atenção e …
2021
[3] The influence of chromosome 4 on metabolism and spatial memory in SHR and SLA16 rat strains
2019
[4] Efeitos do tratamento agudo com MK-801 na inibição por pré-pulso em ratos da linhagem SHR e SLA16
2019
[5] Effects of Repeated Treatment with Midazolam in SHR and SLA16 Rat Strains in the Triple Test
Behavior Genetics, 2018
[6] Estudo da alfa-sinucleína e do sistema dopaminérgico nas linhagens de ratos isogênicas SHR e SLA16
2018
[7] Efeitos da administração intranasal de MPTP em ratas SHR, SLA16 e Wistar: Influência de fatores genéticos e ambientais em um modelo animal da doença de …
2018
[8] The Quinpirole Hypolocomotive Effects are Strain and Route of Administration Dependent in SHR and SLA16 Isogenic Rats
Behavior Genetics, 2017
[9] Genetic evidence for chromosome 4 loci influencing learning and memory
Neurobiology of Learning and Memory, 2016
[10] INVESTIGAÇÃO DA PARTICIPAÇÃO DO RECEPTOR DOPAMINÉRGICO D2 NAS DIFERENÇAS COMPORTAMENTAIS, RELACIONADAS À ANSIEDADE/ …
2015
[11] Investigação da participação do receptor dopaminérgico D2 nas diferenças comportamentais, relacionadas à ansiedade, das linhagens SHR e SLA16
2015

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.