American Journal of Analytical Chemistry

Volume 5, Issue 5 (April 2014)

ISSN Print: 2156-8251   ISSN Online: 2156-8278

Google-based Impact Factor: 1.71  Citations  h5-index & Ranking

Stress Degradation Studies on Lisinopril Dihydrate Using Modified Reverse Phase High Performance Liquid Chromatography

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DOI: 10.4236/ajac.2014.55039    6,564 Downloads   8,892 Views  Citations
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ABSTRACT

A simple, precise, accurate and sensitive reverse phase high performance liquid chromatographic method for simultaneous estimation of lisinopril dihydrate and its degradation products occuring under different ICH prescribed stress conditions has been modified. Drug was resolved on a C18 column, utilizing modified mobile phase of tetra butyl ammonium hydroxide solution and acetonitrile. Ultra violet detection was carried out at 210 nm. The method was modified with respect to linearity, precision, accuracy, selectivity, specificity and ruggedness. The results obtained revealed that lisinopril dihydrate was an active product slightly changed under stress conditions.

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Adam, E. (2014) Stress Degradation Studies on Lisinopril Dihydrate Using Modified Reverse Phase High Performance Liquid Chromatography. American Journal of Analytical Chemistry, 5, 316-322. doi: 10.4236/ajac.2014.55039.

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