Prolonged QTc Interval Is an Electrophysiological Hallmark of Cirrhotic Cardiomyopathy - Open Journal of Internal Medicine

OJIM > Vol.4 No.1, March 2014

Open Journal of Internal Medicine

Volume 4, Issue 1 (March 2014)

ISSN Print: 2162-5972 ISSN Online: 2162-5980

Google-based Impact Factor: 0.49 Citations

Prolonged QTc Interval Is an Electrophysiological Hallmark of Cirrhotic Cardiomyopathy ()

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DOI: 10.4236/ojim.2014.41006 4,474 Downloads 6,500 Views Citations

Author(s)

Adnan Bashir Bhatti, Farhan Ali, Siddique Akbar Satti

Affiliation(s)

Capital Development Authority (CDA) Hospital, Islamabad, Pakistan.

ABSTRACT

BACKGROUND: Cirrhotic Cardiomyopathy is a relatively ill-characterized condition, which is often under-diagnosed due to absence of defined diagnostic criteria. ECG showing corrected QT Interval prolongation is the most suitable available option for diagnosis of this condition. OBJECTIVE: To determine the frequency of corrected QT interval prolongation in patients with liver cirrhosis. METHODOLOGY: Patients (n = 166) with confirmed cirrhosis, 30 years or older, presented in the outpatient and emergency department of medicine at Capital Hospital Islamabad between 1 October 2011 and 30 September 2012, were enrolled in this cross-sectional study after taking consent. ECG was done using calibrated ECG machine, and the QT Interval was measured. Corrected QT was calculated using Bazett’s formula and a QTc of more than 0.44 seconds was considered as being prolonged. RESULTS: The mean age of the patients was 57.05 ± 12.03 years. The corrected QT Interval varied from 337 ms to 560 ms. The mean QTc Interval was 429.92 ms ± 45.11. QTc was prolonged in 41 out of 166 patients (24.7%). Frequency of QTc prolongation was 4.5% in Child Pugh Grade A, 23.2% in Child Pugh Grade B, and 32.0% in Child Pugh Grade C. Association of Child Pugh Scoring with QTc prolongation was determined and found to be statistically significant (P < 0.05). CONCLUSION: QTc interval was prolonged in 24.7% of cirrhotic patients in our study. There was a significant increase in frequency with worsening of Child Pugh Grade, thereby indicating an association between QTc prolongation and the severity of cirrhosis.

KEYWORDS

Cirrhosis; QT Interval; Cirrhotic Cardiomyopathy

Share and Cite:

Bashir Bhatti, A. , Ali, F. and Akbar Satti, S. (2014) Prolonged QTc Interval Is an Electrophysiological Hallmark of Cirrhotic Cardiomyopathy. Open Journal of Internal Medicine, 4, 33-39. doi: 10.4236/ojim.2014.41006.

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