The objective of this study was designed to
investigate, evaluate the effect of vitamin E on streptozotocin (STZ)-induced diabetic rats by
showing significant changes in
blood glucose, water, food intake, lipid profile, serum urea and ceratinine
level, and antioxidant enzyme parameters activity. Streptozotocin (STZ)-induced toxicity was
studied in male Waster rats; each divided into four
groups: G1, GII, GIII, and GIV. Control rats GI, rats treated with vitamin E (GII), STZ-induced diabetic rats (GIII), and STZ-induced diabetic rats
treated with vitamin E (G1V). Moreover, vitamin E reduced (p < 0.05) blood glucose and urea, thus, our study improved the lipid
profile (reduced the serum levels of amount of total
cholesterol, LDL, VLDL, cholesterol and triacyglycerols, and increased HDL
cholesterol) and increased total amount protein in STZ-induced diabetic rats (GIV).
Vitamin prevented modification in the activity of superoxide dismutase (SOD)
and glutathione peroxidase (GSX-Px) and in the
concentration of the lipid hydroperoxide. Finally the study suggested that
vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression
of oxidative stress in STZ-induced diabetic rats.