Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes ()
ABSTRACT
Background: Increased
glomerular filtration rate (GFR) commonly develops in early diabetes and is
closely correlated with the development of diabetic nephropathy. Objective: The
aim was to study the relationship between GFR, C-peptide level and other
parameters at diagnosis of Type 1 diabetes. Methods: We determined GFR, Cpeptide
level, glycated hemoglobin (HbA1c), body mass index (BMI) SDS and loss of
weight at diagnosis of Type 1 diabetes in 495 children (231 females). Linear
and multiple regression analysis was used to test for the associations between
GFR and other parameters. Results: In the 495 patients, GFR median
(interquartile range) was increased vs normal values (p = 0.0001). GFR was
significantly negatively correlated with age (p < 0.001) and C-peptide level
(p = 0.001), and positively correlated with weight loss (p = 0.02). The
multiple regression analysis showed that age (p = 0.001) and C-peptide level (p
= 0.05) were independently and negatively related to GFR. Conclusions: This
study shows that, at onset of Type 1 diabetes, higher the GFR, younger the age
and lower the C-peptide level are. The role of this hyperfiltration in the
development of later nephropathy and the putative preventive effect of
C-peptide administration need to be evaluated.
Share and Cite:
Messaaoui, A. , Tenoutasse, S. , Mélot, C. and Dorchy, H. (2014) Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes.
Journal of Diabetes Mellitus,
4, 50-53. doi:
10.4236/jdm.2014.41009.