Advances in Bioscience and Biotechnology

Volume 5, Issue 1 (January 2014)

ISSN Print: 2156-8456   ISSN Online: 2156-8502

Google-based Impact Factor: 0.87  Citations  h5-index & Ranking

Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review

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DOI: 10.4236/abb.2014.51006    4,204 Downloads   6,202 Views  

ABSTRACT

Deoxyribonucleic acid (DNA) or oligonucleotides, can be modified in several ways as chemical degradation by electrophilic reaction, attack of radicals, hydrolytic deamination or oxidative damage caused by ionizing radiation. This work discussed these degradation mechanisms, determining the effects on these biomolecules. The actual knowledge about DNA damages only permits partial enzymatic repair treatments.

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Reyes, J. , Medina Orozco, L. , Jaramillo, M. , Romero, I. and Soriano, A. (2014) Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review. Advances in Bioscience and Biotechnology, 5, 36-39. doi: 10.4236/abb.2014.51006.

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