The structure is the basic attribute of everything. The structure of logistics network is composed of logistics nodes and logistics routes, however the logistics cost mainly happens on the function the logistics route undertakes. So logistics routing optimization is the key to reduce logistics cost. As logistics is the hygiene factor of regional economic development, this article studied on logistics routing optimization by applying the demand of the regional economic development as a starting point, using the spatial interaction theory, building a method of the regional logistics link optimization based on the gravity model, and taking blue and yellow zones as the background to illustrate the rationality and feasibility of this method.