Author(s)

Pranab Jyoti Das, Jupitara Das, Munni Ghosh, Sabera Sultana

Department of Chemistry, Gauhati University, Guwahati, India.
Indian Institute of Technology, Guwahati, India.

Secondary amine based ionic liquid and defective Keggin type heteropoly acid (HPA) are separately used for efficient one-pot four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles assisted by microwave (MW). Eco-friendly solvent free procedure, short reaction time, high yield of products and reusability of catalysts are important features of the synthesis. A comparative study on the efficiency of the two catalysts is reported. This work further demonstrates the alternate use of urea, instead of often used ammonium acetate, as source of nitrogen.

Ionic Liquids; Keggin Heteropolyacid; Microwave; Tetrasubstituted Imidazole; Solvent Free Synthesis; Multicomponent Reaction

P. Jyoti Das, J. Das, M. Ghosh and S. Sultana, "Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid," Green and Sustainable Chemistry, Vol. 3 No. 4A, 2013, pp. 6-13. doi: 10.4236/gsc.2013.34A002.