The most common clinical manifestation of gram negative Salmonella typhimurium infection is gastroenteritis. In Poland extraintestinal infections occur in about 0.4% of cases of reported salmonellosis. Poor personal hygiene practices of parents are the most common cause of Salmonella spp. infections in the neonatal period. The neonatal salmonellosis is significantly more frequently reported in endemic areas such as Central Africa or India, than in Poland. The authors present a case of a newborn with Salmonella typhimurium sepsis, who was treated in the Department of Intensive Care and Congenital Malformations of the Neonates and Infants, Polish Mother’s Memorial Research Institute.